Dear Viewers,

My name is Mahesh Sharma, with this Website; I request to reconsider me for the recruitment in any fild of Bioinformatics.

As the world constantly demands more specific biological data at faster speeds, all of this is possible only due to Bioinformatician. The organization of Biological data and Analysis lead the R&D industry into the Bioinformatics.

I have done M.Sc. in Bioinformatics, before this I did B.Sc. in Microbiology with pharmaceutical chemistry. While studying Both Computer and Biology I use to developed my interest in organize some Expert System on Biological data and tool to help in Biology. To improve my Programming skills I have been trainees on DOTNET Technology at Alien SoftNet    Technology Pvt. Ltd. As Bioinformatics demand PERL so I m very comfortable with PERL basic & have some Idea about data parsing and developing. Little bit knowledge about SQL-2005 to organize data and run most common Query. I m able to work with HTML also I developed a website MicroInformatics witch have some Experimental detail of Microbiology and run on client system. I can search Batter result from NCBI, EBI and internet. Working with computer I have been well known with Windows and can solve all problems like software and hardware both.

My M.Sc. research project was on Pharmacophore Modeling in LEUKEMIA Diseases. In this project after the analysis of Leukemia we have identified three genetically linked genes (ABL1 chro-9, AFF1 chro-4, MKL1 chro-22). These genes are responsible for Leukemia.  From these genes we find out some interest Protein with more than four ligands (Protein 2FO0, ligand: MYR1, P162, SEP69, GOL3, GOL4, Protein: 2G1T, Ligand: 1121202, -101, 401, GLU105, GLU104, GLU111, Protein: 2GQG, Ligand: 1N1501, PTR393-A, B, GOL1, and Protein: 2HYY, Ligand: STI600-A,-B,-C,-D). After this, a best suitable Pharmacophore Model was prepared with the help of Ligandscout 1.03 Tool. Now if any drug can bind with this Pharmacophore then we can have 100% treatment of genetically linked LEUKEMIA. In this whole project study, we have referred to NCBI, TIGR, EBI, HPRD, and SWISS-PROT for data base.

My knowledge in Bioinformatics, interest in experiments, and advance knowledge in Computer Aided Drug Designing, Molecular Modeling, Computational Biology, Immunology, Recombinant DNA Technology, Genomics & Proteomics, Metabolic pathways, Gene Sequence Analysis, Protein Sequence Analysis, Discovery of genuine drugs for LEUKEMIA using Bioinformatics Tools, Phylogenetic Analysis, Virtual Screening and Docking. Motivate me to pursue a career in this field.

Please find the resume at resumelink.

Yours Sincerely

Mahesh Sharma

M.Sc. Bioinformatics

B.Sc. Microbiology + Pharmachemistry

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